Modern HPLC for Practicing Scientists by Michael W. Dong
Author:Michael W. Dong
Language: eng
Format: epub, pdf
ISBN: 9781119293606
Publisher: Wiley
Published: 2016-04-04T16:00:00+00:00
6.3.5 Assay of Preservatives
A preservative is a substance that extends the shelf-life of drug products by preventing oxidation or inhibiting microbial growth.14 Preservatives must be monitored in the products since they are considered to be active components. Generic HPLC assays are typically developed for preservatives such as butylated hydroxy toluene (BHT), an antioxidant for solid dosage forms, and antimicrobials such as parabens, sodium benzoate, or sorbic acid in liquid formulations. For these additive components, typical assay specifications are 85–115% of label claim.
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